Trityl chloride → 4-Iodo-5-methyl-1-trityl-1H-imidazole

To a cold (0° C.) solution of 4-iodo-5-methylimidazole (5.0 g, 24.0 mmol) and triethylamine (5.0 mL, 36.0 mmol) in CH2Cl2 (100 mL) and 1,4-dioxane (50 mL) was added trityl chloride (8.0 g, 29.0 mmol). The resultant mixture was stirred for 2 hours and quenched with ice and extracted with diethyl ether. The organic extracts were washed with sat. aq. NaHCO3, dried (K2CO3) and the solvent evaporated in vacuo. The product mixture was concentrated onto silica gel and chromatographed (Silica gel, 30-50% EtOAc in hexanes) to afford the title compound as a pale yellow powder.

1. customquenched with ice
2. extractionextracted with diethyl ether
3. washThe organic extracts were washed with sat. aq. NaHCO3
4. dry with materialdried (K2CO3)
5. customthe solvent evaporated in vacuo
6. concentrationThe product mixture was concentrated onto silica gel
7. customchromatographed (Silica gel, 30-50% EtOAc in hexanes)

ORD-Eintrag

ord-d934be950e9d4947b09c11efd6ba48e2

Quelldatensatz

uspto-grants-2000_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06080870