Diethyl Ether → Methyl 3-butanoyl-4-hydroxybenzoate

HRID 14248Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 14248
[C:1]([CH:6]1[CH2:11][C:10](O)([C:12]([O:14][CH3:15])=[O:13])[CH:9]=[CH:8][C:7]1=[O:17])(=[O:5])[CH2:2][CH2:3][CH3:4].B(F)(F)F.O(CC)CC>C1C=CC=CC=1>[C:1]([C:6]1[CH:11]=[C:10]([CH:9]=[CH:8][C:7]=1[OH:17])[C:12]([O:14][CH3:15])=[O:13])(=[O:5])[CH2:2][CH2:3][CH3:4]

Komponenten

5

Edukt 3

HCID 3283Diethyl EtherHCID 6356Boron trifluorideHCID 21086214HCID 21086214, Verbindung

Produkt 1

HCID 12533653Methyl 3-butanoyl-4-hydroxybenzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

To a stirred solution of methyl 5-butyryl-1-hydroxy-4-oxocyclohex-2-ene-1-carboxylate in benzene was added BF3.O(Et)2 (1.3 mL, 10 mmol). The mixture was stirred for 0.25 h and then quenched with saturated sodium bicarbonate followed by extraction with dichloromethane. The organic layer was dried (sodium sulfate), filtered, and concentrated under reduced pressure to afford methyl 3-butyryl-4-hydroxybenzoate which was used without further purification or characterization.

Aufarbeitung

  1. customquenched with saturated sodium bicarbonate
  2. extractionfollowed by extraction with dichloromethane
  3. dry with materialThe organic layer was dried (sodium sulfate)
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d45898382cf545c6a8d183ff834260e4
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727997B2

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