Lithium Hydroxide → HCID 68406214, Verbindung

HRID 1425283Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1425283
[C:1]([C:4]1[S:8][C:7]([N:9]2[CH2:14][CH2:13][C@H:12]([NH:15][C:16]([C:18]3[NH:19][C:20]([CH2:24][CH3:25])=[C:21]([Cl:23])[N:22]=3)=[O:17])[C@H:11]([O:26][CH3:27])[CH2:10]2)=[N:6][C:5]=1[C:28]([O:30]CC)=[O:29])(=[O:3])[CH3:2].[OH-].[Li+]>CO.C1COCC1>[C:1]([C:4]1[S:8][C:7]([N:9]2[CH2:14][CH2:13][C@H:12]([NH:15][C:16]([C:18]3[NH:19][C:20]([CH2:24][CH3:25])=[C:21]([Cl:23])[N:22]=3)=[O:17])[C@H:11]([O:26][CH3:27])[CH2:10]2)=[N:6][C:5]=1[C:28]([OH:30])=[O:29])(=[O:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 3939Lithium HydroxideHCID 86648763Ethyl cis(+/-)-5-acetyl-2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-1,3-thiazole-4-carboxylate

Produkt 1

HCID 68406214HCID 68406214, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Ethyl cis(±)-5-acetyl-2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-1,3-thiazole-4-carboxylate obtained in Example (190b) (54 mg, 0.11 mmol) was dissolved in methanol (2 ml) and THF (2 ml). A 2 N aqueous lithium hydroxide solution (2 ml) was added, and the mixture was stirred at room temperature overnight. The organic solvent was evaporated under reduced pressure, followed by neutralization with 1 N hydrochloric acid. The resulting solid was collected by filtration and washed with distilled water, to obtain the title compound as a solid.

Aufarbeitung

  1. customThe organic solvent was evaporated under reduced pressure
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed with distilled water

Quellen und Nachweise

ORD-Eintrag
ord-1c614474b3514323b5d7b1aa3028ba4c
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08927588B2

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