Sodium borohydride → 2-(4-(aminomethyl)-3-fluorophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

HRID 1428783Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1428783
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:31])[C:10]([NH:12][CH2:13][C:14]2[C:15]([C:24]3[CH:25]=[C:26]([CH3:30])[CH:27]=[CH:28][CH:29]=3)=[N:16][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:18][CH:19]=2)=[O:11])=[CH:5][C:4]=1[F:32])#[N:2].[BH4-].[Na+]>C(O)C.[NiH6-5]Cl>[NH2:2][CH2:1][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:31])[C:10]([NH:12][CH2:13][C:14]2[C:15]([C:24]3[CH:25]=[C:26]([CH3:30])[CH:27]=[CH:28][CH:29]=3)=[N:16][C:17]([C:20]([F:23])([F:21])[F:22])=[CH:18][CH:19]=2)=[O:11])=[CH:5][C:4]=1[F:32]

Komponenten

5

Edukt 2

HCID 4311764Sodium borohydrideHCID 866802252-(4-cyano-3-fluorophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Produkt 1

HCID 866802262-(4-(aminomethyl)-3-fluorophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178479586HCID 178479586, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

Nickel(II) chloride hexahydride (1 equiv.) and 2-(4-cyano-3-fluorophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide are stirred in anhydrous ethanol during 15 minute for activation. Sodium borohydrid (7 equiv.) is added on it and mixture stirred for 2 h. Adding celite to the reaction and filter it using celite packed filter, washing with ethanol. The reaction mixture is purified after concentration to obtain 2-(4-(aminomethyl)-3-fluorophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide.

Aufarbeitung

  1. additionAdding celite
  2. customto the reaction
  3. filtrationfilter it
  4. filtrationusing celite packed filter
  5. washwashing with ethanol
  6. customThe reaction mixture is purified
  7. concentrationafter concentration

Quellen und Nachweise

ORD-Eintrag
ord-0ed009c570f74694a781f48e9162d621
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08937092B2

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