2-Methoxybenzenesulfonyl Chloride → 4-(4-Bromobenzyl)-5-((2-methoxyphenyl)sulfonyl)-3,4,5,6-tetrahydro-1H-benzo-[f][1,4]oxazocine

HRID 1429367Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1429367
[Br:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][CH:7]2[NH:14][CH2:13][C:12]3[CH:15]=[CH:16][CH:17]=[CH:18][C:11]=3[CH2:10][O:9][CH2:8]2)=[CH:4][CH:3]=1.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[S:29](Cl)(=[O:31])=[O:30]>C(#N)C.CN(C1C=CN=CC=1)C>[Br:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][CH:7]2[N:14]([S:29]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[O:22][CH3:21])(=[O:31])=[O:30])[CH2:13][C:12]3[CH:15]=[CH:16][CH:17]=[CH:18][C:11]=3[CH2:10][O:9][CH2:8]2)=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 37458512-Methoxybenzenesulfonyl ChlorideHCID 674173634(4-Bromobenzyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

Produkt 1

HCID 674165884-(4-Bromobenzyl)-5-((2-methoxyphenyl)sulfonyl)-3,4,5,6-tetrahydro-1H-benzo-[f][1,4]oxazocineAusbeute 38 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To a mixture of compound 3l (900 mg, 2.7 mmol) and TEA (546 mg, 5.4 mmol) in acetonitrile (30 mL) was added 2-methoxybenzene sulfonyl chloride (559 mg, 2.7 mmol) and catalytic amount of DMAP. The reaction mixture was stirred at rt overnight. The solvent was evaporated in vacuo and purified by CC to give 3 as a white solid (510 mg, 38% yield).

Aufarbeitung

  1. customThe solvent was evaporated in vacuo
  2. custompurified by CC

Quellen und Nachweise

ORD-Eintrag
ord-b1e313ab658c485890c85a8ff3cdb601
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08940722B2

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