HCID 86701036, Verbindung → 1,1-Dimethylethyl N-[1-(2-hydroxyethyl)cyclopropyl]carbamate

HRID 1430702Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1430702
[Si]([O:8][CH2:9][CH2:10][C:11]1([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:13][CH2:12]1)(C(C)(C)C)(C)C>C(Cl)Cl>[OH:8][CH2:9][CH2:10][C:11]1([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:19])([CH3:18])[CH3:20])[CH2:12][CH2:13]1

Komponenten

3

Edukt 1

HCID 86701036HCID 86701036, Verbindung

Produkt 1

HCID 129931391,1-Dimethylethyl N-[1-(2-hydroxyethyl)cyclopropyl]carbamateAusbeute 60,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of tert-butyl 1-(2-(tert-butyldimethylsilyloxy)ethyl)cyclopropylcarbamate (11.9 g, 37.8 mmol) and 3HF.TEA (22.0 g) in DCM (50 mL) was stirred at rt for 17 hrs. The mixture was concentrated and the residue was purified by silica gel column chromatography (0˜20% gradient elution EtOAc/petroleum ether) to afford tert-butyl 1-(2-hydroxyethyl)cyclopropylcarbamate (4.6 g, 60%) as a white solid.

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. customthe residue was purified by silica gel column chromatography (0˜20% gradient elution EtOAc/petroleum ether)

Quellen und Nachweise

ORD-Eintrag
ord-c78d99ac93a94ad4a214bcb0564b6f65
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08940897B2

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