Cesium carbonate → Methyl 2-(4-bromo-5,7-difluoro-3-methylquinolin-2-ylamino)acetate

Temperatur

70 °C

2-Isobutyrylcyclohexanone (0.086 mL, 0.51 mmol), glycine methyl ester hydrochloride (480 mg, 3.9 mmol), 2,4-dibromo-5,7-difluoro-3-methylquinoline (870 mg, 2.6 mmol), copper(I) iodide (24 mg, 0.13 mmol) and cesium carbonate (2.5 g, 7.70 mmol) were slurried in DMF (3.0 mL) and stirred in an oil bath at 70° C. for 2 h. Another aliquot of copper(I) iodide (24 mg, 0.13 mmol) and 2-isobutyryl-cyclohexanone (0.086 mL, 0.51 mmol) were added and heated for an additional 1.5 h. No further progress was observed. The reaction mixture was then diluted with water and extracted with EtOAc (2×100 mL). The combined organic layers were washed with 1N lithium chloride (1×50 mL) and brine (1×50 mL) and dried over magnesium sulfate. The residue was then purified by medium pressure chromatography (silica gel, 0 to 40% EtOAc:hexanes) to give methyl 2-(4-bromo-5,7-difluoro-3-methylquinolin-2-ylamino)acetate. Mass Spectrum (ESI) m/e=347.0 (M+1).

1. temperatureheated for an additional 1.5 h
2. extractionextracted with EtOAc (2×100 mL)
3. washThe combined organic layers were washed with 1N lithium chloride (1×50 mL) and brine (1×50 mL)
4. dry with materialdried over magnesium sulfate
5. customThe residue was then purified by medium pressure chromatography (silica gel, 0 to 40% EtOAc:hexanes)

ORD-Eintrag

ord-87ac670275734f00ac54395ac4d1797d

Quelldatensatz

uspto-grants-2015_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08940724B2