Ammonium Chloride → 4-Chloropyridine-2-carboximidamide hydrochloride

HRID 1431925

Reaktionsgleichung

Reaktionsgleichung von HRID 1431925
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]#[N:9])[CH:3]=1.C[O-].[Na+].[Cl-].[NH4+:14]>CO>[ClH:1].[C:8]([C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][N:5]=1)(=[NH:14])[NH2:9]

Komponenten

5

Edukt 3

HCID 25517Ammonium ChlorideHCID 6933424-Chloro-2-pyridinecarbonitrileHCID 10942334Sodium Methoxide

Produkt 1

HCID 218820004-Chloropyridine-2-carboximidamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

6.93 g (50 mmol) of 4-chloro-2-cyanopyridine in 40 ml of methanol are treated for one hour with 0.27 g (5 mmol) sodium methoxide. After the addition of 3.00 g (56 mmol) of ammonium chloride, refluxing is carried out for two hours. The volatile components are then removed in vacuo. The 2-amidino-4-chloropyridine hydrochloride so obtained is reacted without further purification.

Aufarbeitung

  1. temperaturerefluxing
  2. customThe volatile components are then removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-240063da68164b27b7977e65dd3e8129
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612010B2

Verknüpfte Notizen

Wird geladen…