4-Fluorobenzaldehyde → N-(2-{2-[(4-Fluoro-phenyl)-(4-hydroxy-5-isopropyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-methyl]-1H-indol-3-yl}-ethyl)-acetamide

HRID 1432443

Reaktionsgleichung

Reaktionsgleichung von HRID 1432443
[OH:1][C:2]1[CH:6]([CH:7]([CH3:9])[CH3:8])[NH:5][C:4](=[O:10])[CH:3]=1.[F:11][C:12]1[CH:19]=[CH:18][C:15]([CH:16]=O)=[CH:14][CH:13]=1.[NH:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:22]([CH2:29][CH2:30][NH:31][C:32](=[O:34])[CH3:33])=[CH:21]1>>[F:11][C:12]1[CH:19]=[CH:18][C:15]([CH:16]([C:3]2[C:4](=[O:10])[NH:5][CH:6]([CH:7]([CH3:9])[CH3:8])[C:2]=2[OH:1])[C:21]2[NH:20][C:28]3[C:23]([C:22]=2[CH2:29][CH2:30][NH:31][C:32](=[O:34])[CH3:33])=[CH:24][CH:25]=[CH:26][CH:27]=3)=[CH:14][CH:13]=1

Komponenten

4

Edukt 3

HCID 680234-FluorobenzaldehydeHCID 70547N-AcetyltryptamineHCID 566041114-Hydroxy-5-isopropyl-1,5-dihydro-pyrrol-2-one

Produkt 1

HCID 57933472N-(2-{2-[(4-Fluoro-phenyl)-(4-hydroxy-5-isopropyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-methyl]-1H-indol-3-yl}-ethyl)-acetamide

Versuchsvorschrift

Using general procedure C, 4-hydroxy-5-isopropyl-1,5-dihydro-pyrrol-2-one (Lit. 11) was reacted with 4-fluoro-benzaldehyde and N-[2-(1H-indol-3-yl)-ethyl]-acetamide to give the title compound as a yellow solid. MS: 450.3 ([M+H]+).

Quellen und Nachweise

ORD-Eintrag
ord-e2e8a92d5d8a41ee89a1491bf99577e9
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612099B2

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