Sodium borohydride → HCID 54519295, Verbindung

HRID 1432955Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1432955
[BH4-].[Na+].[C:3]([O:7][C:8]([N:10]1[C:18]2[CH:17]=[CH:16][N:15]=[CH:14][C:13]=2[CH:12]=[C:11]1[CH2:19][N:20]1[C:25](=[O:26])[CH2:24][N:23]([S:27]([CH:30]=[CH:31][C:32]2[S:33][C:34]([Cl:37])=[CH:35][CH:36]=2)(=[O:29])=[O:28])[CH2:22][CH:21]1[C:38](OC)=[O:39])=[O:9])([CH3:6])([CH3:5])[CH3:4].C(OC(N1C2C=CN=CC=2C=C1CN1C(=O)CNCC1C(OC)=O)=O)(C)(C)C.ClC1SC(C=CS(Cl)(=O)=O)=CC=1>CO>[C:3]([O:7][C:8]([N:10]1[C:18]2[CH:17]=[CH:16][N:15]=[CH:14][C:13]=2[CH:12]=[C:11]1[CH2:19][N:20]1[C:25](=[O:26])[CH2:24][N:23]([S:27]([CH:30]=[CH:31][C:32]2[S:33][C:34]([Cl:37])=[CH:35][CH:36]=2)(=[O:29])=[O:28])[CH2:22][CH:21]1[CH2:38][OH:39])=[O:9])([CH3:5])([CH3:6])[CH3:4]

Komponenten

6

Edukt 4

HCID 4311764Sodium borohydrideHCID 54182443HCID 54182443, VerbindungHCID 544630642-(5-Chlorothiophen-2-yl)ethenesulfonyl chlorideHCID 69028555HCID 69028555, Verbindung

Produkt 1

HCID 54519295HCID 54519295, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Sodium borohydride (0.005 g, 0.13 mmol) is added to a solution of 2-{4-[2-(5-chloro-thiophen-2-yl)-ethenesulfonyl]-2-(±)-methoxycarbonyl-6-oxo-piperazin-1-ylmethyl}-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester (0.04 g, 0.07 mmol), (prepared from 2-(2-(±)-methoxycarbonyl-6-oxo-piperazin-1-ylmethyl)-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester, EXAMPLE 71, and 2-(5-chloro-thiophen-2-yl)-ethenesulfonyl chloride, EXAMPLE 3, using the procedure described in EXAMPLE 214, Part A) in MeOH (3 mL) at RT. The reaction mixture is stirred for 6 h then quenched with water and concentrated in vacuo. The crude product (0.04 g) is taken onto the next step without further purification.

Aufarbeitung

  1. customat RT
  2. customthen quenched with water
  3. concentrationconcentrated in vacuo
  4. customThe crude product (0.04 g) is taken onto the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-bee0f9d895c041f8850757b9cd95aef4
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612075B2

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