Acetic Acid → 1-[4-(4-Aminoquinazoline-7-ylmethyl)-3-oxo-2-propyl-piperazine-1-yl]-3-(5-chloro-thiophen-2-yl)-2-fluoro-propane-1,3,dione

Reaktionsgleichung

[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH2:18][CH2:17][N:16]([C:19](=[O:29])[CH2:20][C:21]([C:23]4[S:24][C:25]([Cl:28])=[CH:26][CH:27]=4)=[O:22])[CH:15]([CH2:30][CH2:31][CH3:32])[C:14]3=[O:33])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[H-].[Na+].C1C=CC(S(N(S(C2C=CC=CC=2)(=O)=O)[F:46])(=O)=O)=CC=1.C(O)(=O)C>C1COCC1>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH2:18][CH2:17][N:16]([C:19](=[O:29])[CH:20]([F:46])[C:21]([C:23]4[S:24][C:25]([Cl:28])=[CH:26][CH:27]=4)=[O:22])[CH:15]([CH2:30][CH2:31][CH3:32])[C:14]3=[O:33])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1