Carbon tetrabromide → HCID 60209911, Verbindung

HRID 1433100Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1433100
O[CH2:2][C:3]1[CH:4]=[N:5][C:6]([S:9][CH3:10])=[N:7][CH:8]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:31]>C1C=CC=CC=1>[Br:31][CH2:2][C:3]1[CH:4]=[N:5][C:6]([S:9][CH3:10])=[N:7][CH:8]=1

Komponenten

5

Edukt 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 22050485(2-(Methylsulfanyl)pyrimidin-5-yl)methanol

Produkt 1

HCID 60209911HCID 60209911, VerbindungAusbeute 61 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

5-hydroxymethyl-2-methylthiopyrimidine (0.1 g, 0.61 mmol), triphenylphosphine (0.45 g, 1.7 mmol) and carbon tetrabromide (0.28 g, 0.85 mmol) are stirred in benzene (5 mL) for 24 h. The mixture is evaporated and the residue is purified by flash chromatography (silica gel, 4:1 hexanes/ethyl acetate) to provide the intermediate title compound as a white solid (0.08 g, 61%). MS (ES), 219/221 [M+H]+ (Br).

Aufarbeitung

  1. customThe mixture is evaporated
  2. customthe residue is purified by flash chromatography (silica gel, 4:1 hexanes/ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-e5c24fd45b004b6bb157294d4c716446
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612075B2

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