Tert-Butylamine → 2-bromo-N-tert-butyl-4-trifluoromethyl-benzenesulfonamide

HRID 1433197Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1433197
[Br:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[S:12](Cl)(=[O:14])=[O:13].[C:16]([NH2:20])([CH3:19])([CH3:18])[CH3:17]>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[S:12]([NH:20][C:16]([CH3:19])([CH3:18])[CH3:17])(=[O:14])=[O:13]

Komponenten

4

Edukt 2

HCID 6385Tert-ButylamineHCID 27786112-Bromo-4-(trifluoromethyl)benzenesulfonyl chloride

Produkt 1

HCID 579349362-bromo-N-tert-butyl-4-trifluoromethyl-benzenesulfonamideAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 2-bromo-4-(trifluoromethyl)benzenesulfonyl chloride (10 g, 0.031 mol) in CH2Cl2 (100 mL) was added t-butylamine (8.0 mL, 0.076 mol) at 0° C. The reaction mixture was allowed to warm to room temperature, and stirred for 30 min. A white precipitate formed and was filtered, and the filtrate was concentrated in vacuo to afford the title compound as a yellow oil (11 g, 100%).

Aufarbeitung

  1. customA white precipitate formed
  2. filtrationwas filtered
  3. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-eb237e66be9a4ee78ea641584e05666b
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612211B2

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