1-Bromo-4-fluoro-2-nitrobenzene → HCID 23087411, Verbindung

HRID 1433866

Reaktionsgleichung

Reaktionsgleichung von HRID 1433866
Br[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].C([Sn](CCCC)(CCCC)C1C=CC(F)=CC=1[N+]([O-])=O)CCC.FC(F)(F)S(O[C:41]1[CH2:50][CH2:49][C:48]2[C:43](=[CH:44][CH:45]=[C:46]([O:51][CH3:52])[CH:47]=2)[CH:42]=1)(=O)=O>>[F:8][C:5]1[CH:6]=[CH:7][C:2]([C:41]2[CH2:50][CH2:49][C:48]3[C:43]([CH:42]=2)=[CH:44][CH:45]=[C:46]([O:51][CH3:52])[CH:47]=3)=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1

Komponenten

4

Edukt 3

HCID 27733831-Bromo-4-fluoro-2-nitrobenzeneHCID 153302566-Methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonateHCID 23087155HCID 23087155, Verbindung

Produkt 1

HCID 23087411HCID 23087411, Verbindung

Versuchsvorschrift

Synthesized from 1-bromo-4-fluoro-2-nitrobenzene according to an analogous synthetic method to Preparation Example 76, tributyl(4-fluoro-2-nitrophenyl)tin (7.1 g) and 6-methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonate (2.2 g) were used according to an analogous synthetic method to Preparation Example 77 to provide 3-(4-fluoro-2-nitrophenyl)-7-methoxy-1,2-dihydronaphthalene (1.4 g). The total amount of this compound was used according to an analogous synthetic method to Example 30 to provide the title compound (1.1 g).

Aufarbeitung

  1. customwere used according to an analogous synthetic method to Preparation Example 77

Quellen und Nachweise

ORD-Eintrag
ord-165de24fe0e443f090d1281e4f06cbe7
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612114B2

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