4-Bromo-3-nitrobenzotrifluoride → 7-Methoxy-3-(2-nitro-4-trifluoromethylphenyl)-1,2-dihydronaphthalene

HRID 1433868

Reaktionsgleichung

Reaktionsgleichung von HRID 1433868
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].C([Sn](CCCC)(CCCC)C1C=CC(C(F)(F)F)=CC=1[N+]([O-])=O)CCC.FC(F)(F)S(O[C:47]1[CH2:56][CH2:55][C:54]2[C:49](=[CH:50][CH:51]=[C:52]([O:57][CH3:58])[CH:53]=2)[CH:48]=1)(=O)=O>>[CH3:58][O:57][C:52]1[CH:53]=[C:54]2[C:49]([CH:48]=[C:47]([C:2]3[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=3[N+:12]([O-:14])=[O:13])[CH2:56][CH2:55]2)=[CH:50][CH:51]=1

Komponenten

4

Edukt 3

HCID 5207064-Bromo-3-nitrobenzotrifluorideHCID 153302566-Methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonateHCID 23087363Tributyl(2-nitro-4-trifluoromethylphenyl)tin

Produkt 1

HCID 230874677-Methoxy-3-(2-nitro-4-trifluoromethylphenyl)-1,2-dihydronaphthalene

Versuchsvorschrift

Synthesized from 1-bromo-2-nitro-4-trifluoromethylbenzene according to an analogous synthetic method to Preparation Example 76, tributyl(2-nitro-4-trifluoromethylphenyl)tin (7.4 g) and 6-methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonate (2.2 g) were used according to an analogous synthetic method to Preparation Example 77 to provide 7-methoxy-3-(2-nitro-4-trifluoromethylphenyl)-1,2-dihydronaphthalene (1.5 g). The total amount of this compound was used according to an analogous synthetic method to Example 30 to provide the title compound (1.0 g).

Aufarbeitung

  1. customwere used according to an analogous synthetic method to Preparation Example 77

Quellen und Nachweise

ORD-Eintrag
ord-d00daee45e914c9cbcda05ad34a62def
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07612114B2

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