Ammonium Chloride → 4-amino-2,3-dihydro-1H-inden-2-yl acetate

HRID 1434559

Reaktionsgleichung

Reaktionsgleichung von HRID 1434559
[C:1]([O:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[N+:14]([O-])=O)[CH2:6]1)(=[O:3])[CH3:2].[Cl-].[NH4+]>C(O)C.O.C(OC(=O)C)C.[Fe]>[C:1]([O:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[NH2:14])[CH2:6]1)(=[O:3])[CH3:2]

Komponenten

7

Edukt 2

HCID 25517Ammonium ChlorideHCID 132395834-nitro-2,3-dihydro-1H-inden-2-yl acetate

Produkt 1

HCID 132395844-amino-2,3-dihydro-1H-inden-2-yl acetate

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 23925IronKatalysatorHCID 702EthanolLösungsmittelHCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a mixture of 4-nitro-2,3-dihydro-1H-inden-2-yl acetate (100 mg, 0.45 mmol) and ammonium chloride (100 mg) in ethanol (6 ml) and water (3 ml) was added iron powder (300 mg) portionwise at room temperature. The mixture was stirred at 90° C. for 1 hour, and after cooled to room temperature, the mixture was diluted with ethylacetate. The mixture was filtered through a pad of celite, and the filtrate was washed with brine, dried over MgSO4, filtered, and concentrated under reduced pressure to obtain 4-amino-2,3-dihydro-1H-inden-2-yl acetate.

Aufarbeitung

  1. temperatureafter cooled to room temperature
  2. filtrationThe mixture was filtered through a pad of celite
  3. washthe filtrate was washed with brine
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-57ffff16dce048048ddc75e42ca245dc
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07615557B2

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