Sodium borohydride → HCID 68704632, Verbindung

HRID 1434591Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1434591
[BH4-].[Na+].[CH3:3][S:4]([C:7]1[CH:31]=[CH:30][C:10]2[N:11]([CH:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][C:22]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[O:23])[CH2:16][CH2:15]3)[CH:12]=[N:13][C:9]=2[CH:8]=1)(=[O:6])=[O:5]>C(O)C>[CH3:3][S:4]([C:7]1[CH:31]=[CH:30][C:10]2[N:11]([CH:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH:22]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[OH:23])[CH2:16][CH2:15]3)[CH:12]=[N:13][C:9]=2[CH:8]=1)(=[O:6])=[O:5]

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 57935976HCID 57935976, Verbindung

Produkt 1

HCID 68704632HCID 68704632, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Sodium borohydride (189 mg) was added to a solution of 3-{4-[5-(methylsulfonyl)-1H-benzimidazol-1-yl]piperidin-1-yl}-1-phenylpropan-1-one (2.07 g) in ethanol (40 ml) at 0° C., the mixture was allowed to warm to room temperature and was stirred for 16 hours. The reaction mixture was evaporated to dryness, the residue was redissolved in dichloromethane and washed with water (15 ml) and brine (15 ml) and dried. Removal of the solvent gave 3-{4-[5-(methylsulfonyl)-1H-benzimidazol-1-yl]piperidin-1-yl}-1-phenylpropan-1-ol, 2.1 g, M+H 414.

Aufarbeitung

  1. customThe reaction mixture was evaporated to dryness
  2. dissolutionthe residue was redissolved in dichloromethane
  3. washwashed with water (15 ml) and brine (15 ml)
  4. customdried
  5. customRemoval of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-3ae6950eaf34440caacf3571db161d47
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07615555B2

Notizen zur Reaktion

Wird geladen…