Cyclopropylamine → N-Cyclopropyl-3-methyl-1H-pyrazole-4-carboxamide

Reaktionsgleichung

[CH3:1][C:2]1[C:6]([C:7]([OH:9])=O)=[CH:5][NH:4][N:3]=1.[CH:10]1([NH2:13])[CH2:12][CH2:11]1>>[CH:10]1([NH:13][C:7]([C:6]2[C:2]([CH3:1])=[N:3][NH:4][CH:5]=2)=[O:9])[CH2:12][CH2:11]1

Komponenten

Edukt 2

HCID 69828Cyclopropylamine

HCID 5576005-methyl-1H-pyrazole-4-carboxylic acid

Produkt 1

HCID 178434551N-Cyclopropyl-3-methyl-1H-pyrazole-4-carboxamideAusbeute 94 %

Versuchsvorschrift

Following the same procedure in Example 29 (Step B and C in Method B), using 3-methyl-1H-pyrazole-4-carboxylic acid (252 mg, 2.0 mmol) and cyclopropylamine (285 mg, 5.0 mmol), provided the desired crude compound (310 mg, 94%), which was used in Step A directly.

Quellen und Nachweise

ORD-Eintrag: ord-d5aaa8dc38754dff99f27887215f6e2b
Quelldatensatz: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07615642B2

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