Hydrazine hydrate (1:1) → 5-Chloropyrazine-2-carbohydrazide

HRID 1435782Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1435782
C[O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([Cl:11])=[CH:7][N:6]=1)=O.O.[NH2:13][NH2:14]>CO>[Cl:11][C:8]1[N:9]=[CH:10][C:5]([C:3]([NH:13][NH2:14])=[O:2])=[N:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 406081Methyl 5-chloropyrazine-2-carboxylate

Produkt 1

HCID 457897975-Chloropyrazine-2-carbohydrazide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

5-chloro-pyrazine-2-carboxylic acid methyl ester (10.02 g, 58.25 mmol) and hydrazine monohydrate (12.5 mL, 250 mmol) were dissolved in methanol (400 mL) and the reaction mixture heated to reflux for 48 hours. The reaction mixture was then filtered and the precipitate collected dried in vacuo to yield the title compound, 5.01 g (50%).

Aufarbeitung

  1. temperaturethe reaction mixture heated
  2. temperatureto reflux for 48 hours
  3. filtrationThe reaction mixture was then filtered
  4. customthe precipitate collected
  5. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-90f36bffd1c045c7b8c2b08a54a649d1
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07618972B2

Notizen zur Reaktion

Wird geladen…