Phosphorus oxychloride → 5-Bromo-1-chloro-6-methoxyisoquinoline

HRID 1436012

Reaktionsgleichung

Reaktionsgleichung von HRID 1436012
O=P(Cl)(Cl)Cl.[ClH:6].[Br:7][C:8]1[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[C:14]2[C:9]=1[CH:10]=[CH:11][N+:12]([O-])=[CH:13]2>>[Br:7][C:8]1[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[C:14]2[C:9]=1[CH:10]=[CH:11][N:12]=[C:13]2[Cl:6]

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 688780245-bromo-6-methoxyisoquinoline-N-oxide hydrochloride

Produkt 1

HCID 579564605-Bromo-1-chloro-6-methoxyisoquinolineAusbeute 110,1 %

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

POCl3 (6.5 ml) was added to the 5-bromo-6-methoxyisoquinoline-N-oxide hydrochloride (1.22 g) and the mixture heated at 90° C. for 6 h. Excess POCl3 was removed in vacuo and the remaining solid washed with water, filtered and dried in vacuo to give 5-bromo-1-chloro-6-methoxyisoquinoline (1.26 g).

Aufarbeitung

  1. customExcess POCl3 was removed in vacuo
  2. washthe remaining solid washed with water
  3. filtrationfiltered
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f1c98be2325144308728bc9ba854eb7e
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07618985B2

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