Diethyl Oxalate → 4-(3,4,5-Trifluorobenzyl)morpholine-2,3-dione

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of 2-[(3,4,5-trifluorobenzyl)amino]ethanol (6.91 g) and diethyl oxalate (20 mL) was stirred at 170° C. for one hour. The reaction solution was concentrated under reduced pressure, and then a diethyl ether was added to the residue. The precipitated crystals were collected by filtration and then air-dried to obtain 7.38 g of the title compound.

Herkunft & Nachweise