Hydrochloric Acid → 1-{[(1S,3R)-3-Amino-1-isopropylcyclopentyl]carbonyl}-4-[2-(trifluoromethyl)phenyl]piperidin-4-ol

HRID 1436775Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1436775
[OH:1][C:2]1([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[C:32]([F:35])([F:34])[F:33])[CH2:7][CH2:6][N:5]([C:8]([C@@:10]2([CH:23]([CH3:25])[CH3:24])[CH2:14][CH2:13][C@@H:12]([NH:15]C(=O)OC(C)(C)C)[CH2:11]2)=[O:9])[CH2:4][CH2:3]1.Cl>CCOCC>[NH2:15][C@@H:12]1[CH2:13][CH2:14][C@@:10]([C:8]([N:5]2[CH2:6][CH2:7][C:2]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]([F:35])([F:33])[F:34])([OH:1])[CH2:3][CH2:4]2)=[O:9])([CH:23]([CH3:25])[CH3:24])[CH2:11]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 59833553tert-Butyl [(1R,3S)-3-({4-hydroxy-4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)-3-isopropylcyclopentyl]carbamate

Produkt 1

HCID 579387311-{[(1S,3R)-3-Amino-1-isopropylcyclopentyl]carbonyl}-4-[2-(trifluoromethyl)phenyl]piperidin-4-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a flask containing tert-butyl [(1R,3S)-3-({4-hydroxy-4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)-3-isopropylcyclopentyl]carbamate (0.27 g, 0.54 mmol) was added a 2.00 M solution of HCl in ether (5 mL) and the resulting mixture stirred for 3.5 h. The solution was concentrated to give an oil which was used in the next reaction without purification. MS calculated for C21H29F3N2O2:(M+H)399; found 399.2.

Aufarbeitung

  1. concentrationThe solution was concentrated
  2. customto give an oil which
  3. customwas used in the next reaction without purification

Quellen und Nachweise

ORD-Eintrag
ord-ce2757be35bf4a3abe9e8414697a4564
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07618970B2

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