Trimethyl orthoformate → HCID 23137711, Verbindung

HRID 1436893Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1436893
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15]C(=O)[CH2:13][CH:12]1[C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=1[CH3:25])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO[CH:28]([O:31][CH3:32])[O:29][CH3:30]>CO>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][C:28]([O:29][CH3:30])([O:31][CH3:32])[CH2:13][CH:12]1[C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=1[CH3:25])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 9005Trimethyl orthoformateHCID 21927685HCID 21927685, Verbindung

Produkt 1

HCID 23137711HCID 23137711, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To 132 g of 1-benzyloxycarbonyl-2-(4-fluoro-2-methylphenyl)-4-oxopiperidine were added 650 ml of methanol, 84 ml of trimethoxymethane and 2 g of strongly acidic resin IR-120 (manufactured by Japan Organo Co., Ltd.), and the mixture was stirred at room temperature for 3 days. From the reaction mixture was removed insoluble matters by filtration, and the solvent was removed by distillation under reduced pressure, to give 146 g of 1-benzyloxycarbonyl-2-(4-fluoro-2-methylphenyl)-4,4-dimethoxypiperidine as shown in Table 125 below.

Aufarbeitung

  1. customFrom the reaction mixture was removed insoluble matters
  2. filtrationby filtration
  3. customthe solvent was removed by distillation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-eaad82ecf3334b43a61336aa5a4336d1
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07619092B2

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