Cesium fluoride → 3-Methoxyquinoxalin-5-ol
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:12]=[N:11][C:10]2[C:5](=[C:6]([O:13][Si](C(C)C)(C(C)C)C(C)C)[CH:7]=[CH:8][CH:9]=2)[N:4]=1.[F-].[Cs+]>O1CCCC1.CO>[CH3:1][O:2][C:3]1[CH:12]=[N:11][C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([OH:13])[C:5]=2[N:4]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of (d) (6.95 g, 21 mmol) in tetrahydrofuran/methanol (280 ml/140 ml) was treated with caesium fluoride (4.73 g, 31.4 mmol) and stirred for 18 hours. The mixture was evaporated and the residue partitioned between diethyl ether and dilute aqueous hydrochloric acid. The aqueous phase was further extracted with diethyl ether and the combined extracts dried and evaporated to give an oil (4.2 g).
Aufarbeitung
- customThe mixture was evaporated
- customthe residue partitioned between diethyl ether and dilute aqueous hydrochloric acid
- extractionThe aqueous phase was further extracted with diethyl ether
- customthe combined extracts dried
- customevaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-e352872d5e004c98b4fdadc92c7b0840
- Quelldatensatz
- uspto-grants-2009_11
- Patentnummer
- US07622481B2
Notizen zur Reaktion
Wird geladen…