Potassium Cyanide → 2,4-Difluoro-α-hydroxy-5-methoxybenzeneacetonitrile

HRID 1438149Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1438149
[F:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([O:11][CH3:12])=[CH:6][C:3]=1[CH:4]=[O:5].[C-:13]#[N:14].[K+].OS([O-])=O.[Na+]>C(OCC)(=O)C.O>[F:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([O:11][CH3:12])=[CH:6][C:3]=1[CH:4]([OH:5])[C:13]#[N:14]

Komponenten

6

Edukt 3

HCID 9032Potassium CyanideHCID 23665763Sodium BisulfiteHCID 578038672,4-Difluoro-5-methoxybenzaldehyde

Produkt 1

HCID 579429112,4-Difluoro-α-hydroxy-5-methoxybenzeneacetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To 98A (506 mg, 2.94 mmol) in ethyl acetate (10 mL) was added a solution of KCN (574 mg, 8.82 mmol) and NaHSO3 (917 mg, 8.82 mmol) dissolved in H2O (10 mL). The reaction was stirred at rt for 48 h. It was extracted with ethyl acetate (2×50 mL). The combined organic extracts were dried and concentrated to give 98B as an oil. It was used for next step without purification.

Aufarbeitung

  1. extractionIt was extracted with ethyl acetate (2×50 mL)
  2. customThe combined organic extracts were dried
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-d12308c8358c46069e65ba7d4d129058
Quelldatensatz
uspto-grants-2009_11
Patentnummer
US07622585B2

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