Dimethylamine → 3-Dimethylamino-1-p-fluorophenyl-1-phenyl-propan-2-one

HRID 1438814Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1438814
[CH3:1][NH:2][CH3:3].Br[CH2:5][C:6](=[O:21])[CH:7]([C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C(O)C.CCOCC>[CH3:1][N:2]([CH3:3])[CH2:5][C:6](=[O:21])[CH:7]([C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

5

Edukt 2

HCID 674DimethylamineHCID 125490353-Bromo-1-(4-fluorophenyl)-1-phenylpropan-2-one

Produkt 1

HCID 203090663-Dimethylamino-1-p-fluorophenyl-1-phenyl-propan-2-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

Dimethylamine in ethanol (30 ml s of 33% solution ) was added to a solution of 3-bromo-1-p-fluorophenyl-1-phenyl-propan-2-one (13g) in dry ether. After 45 minutes, the reaction mixture was extracted with dilute hydrochloric acid and ether. Basification of the acid extract and subsequent isolation through ether in the usual manner gave 3-dimethylamino-1-p-fluorophenyl-1-phenyl-propan-2-one isolated as the hydrochloride (5.8g., 53%), m.p. 210° - 220°.

Aufarbeitung

  1. extractionthe reaction mixture was extracted with dilute hydrochloric acid and ether
  2. extractionBasification of the acid extract

Quellen und Nachweise

ORD-Eintrag
ord-b669e8a176724822ad9b31507a442922
Quelldatensatz
uspto-grants-1977_11
Patentnummer
US04056630

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