Sulfuric Acid → 3-(3',4'-Dichloro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester

HRID 1439040Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1439040
Br[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[C:8]([C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([Cl:24])[CH:18]=2)=[CH:13][CH:12]=1)(=[O:10])[CH3:9].S(=O)(=O)(O)O>[Zn].C1C=CC=CC=1>[CH2:6]([O:5][C:3](=[O:4])[CH2:2][C:8]([C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([Cl:24])[CH:18]=2)=[CH:13][CH:12]=1)([OH:10])[CH3:9])[CH3:7]

Komponenten

6

Edukt 3

HCID 1118Sulfuric AcidHCID 7748Ethyl bromoacetateHCID 167688151-[4-(3,4-Dichlorophenyl)phenyl]ethan-1-one

Produkt 1

HCID 544122843-(3',4'-Dichloro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23994ZincKatalysatorHCID 241BenzeneLösungsmittel

Versuchsvorschrift

A mixture of 20 g. of ethyl bromoacetate, 26.5 g. of 4-acetyl-3',4'-dichlorobiphenyl and 8 lg. of zinc foil is added to 100 ml. of benzene and the mixture is stirred and heated under reflux for one hour. It is cooled and dilute sulfuric acid is added to decompose the alcoholate obtained. The organic phase is separated off and, after the customary work up, 3-(3',4'-dichloro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester is obtained.

Aufarbeitung

  1. additionA mixture of 20 g
  2. temperatureheated
  3. temperatureunder reflux for one hour
  4. temperatureIt is cooled
  5. customobtained
  6. customThe organic phase is separated off

Quellen und Nachweise

ORD-Eintrag
ord-41f8819fea85400fad2abe0b64f6da35
Quelldatensatz
uspto-grants-1977_11
Patentnummer
US04057647

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