1-Octanol → Octyl 2-pyrazinecarboxylate

HRID 1440017Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1440017
[CH2:1]([OH:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[N:10]1[CH:15]=[CH:14][N:13]=[CH:12][C:11]=1[C:16](O)=[O:17]>S(=O)(=O)(O)O>[N:10]1[CH:15]=[CH:14][N:13]=[CH:12][C:11]=1[C:16]([O:9][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])=[O:17]

Komponenten

4

Edukt 2

HCID 9571-OctanolHCID 10472-Pyrazinecarboxylic acid

Produkt 1

HCID 465427Octyl 2-pyrazinecarboxylateAusbeute 88,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidKatalysator

Versuchsvorschrift

A four-necked flask was charged with 426 g (3.271 mole) of 1-octanol, 100 g (0.806 mole) of pyrazinecarboxylic acid and 5.0 g (0.05 mole) of concentrated sulfuric acid and the internal temperature was maintained under stirring at 97°-100° C. for 8 hours. The reaction mixture was then cooled and transferred to a separatory funnel, in which it was washed with two portions, or a total of 330 g, of 8% aqueous solution of sodium carbonate. The oil layer which separated was washed with water and subjected to distillation under reduced pressure to give 168 g of octyl pyrazinecarboxylate. Yield: 88% (based on pyrazinecarboxylic acid).

Aufarbeitung

  1. temperaturethe internal temperature was maintained
  2. temperatureThe reaction mixture was then cooled
  3. customtransferred to a separatory funnel, in which it
  4. washwas washed with two portions
  5. customThe oil layer which separated
  6. washwas washed with water
  7. distillationsubjected to distillation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4f7955ab85834912a611039ed6dd0492
Quelldatensatz
uspto-grants-1996_03
Patentnummer
US05496949

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