Hydrazine → HCID 178505511, Verbindung

HRID 1440125

Reaktionsgleichung

Reaktionsgleichung von HRID 1440125
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](O)=[CH:10][C:11](=O)[C:12]([F:15])([F:14])[F:13].[NH2:18][NH2:19]>C(O)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[NH:19][N:18]=[C:11]([C:12]([F:15])([F:14])[F:13])[CH:10]=1

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 699347784-(2,4-Difluorophenyl)-1,1,1-trifluoro-4-hydroxy-3-buten-2-one

Produkt 1

HCID 178505511HCID 178505511, VerbindungAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
95 °C

Versuchsvorschrift

At 24° C., 15.0 g (0.06 mole) of the product of step A was dissolved in 50 mL glacial acetic acid and treated with 2 mL (0.064 mole) anhydrous hydrazine, added over a period of 5 minutes. The reaction was heated to 95° C. for 30 minutes. The reaction was cooled and poured into 300 mL ice water. The slurry was filtered and the cake washed with water and air dried to give 13.86 g (94%) of 5-(2,4-difluorophenyl)-3-(trifluoromethyl)-1H-pyrazole as a white solid, mp 157°-158° C.

Aufarbeitung

  1. additionadded over a period of 5 minutes
  2. temperatureThe reaction was cooled
  3. filtrationThe slurry was filtered
  4. washthe cake washed with water and air
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-22ddc8d1a5384d2b9ad58352f3fa5d2f
Quelldatensatz
uspto-grants-1996_03
Patentnummer
US05496956

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