O-Methyltyramine → HCID 18982108, Verbindung

HRID 1440883Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1440883
[NH2:1][C:2]1[C:7]([N:8]=[O:9])=[C:6]([NH2:10])[N:5]=[C:4](SC)[N:3]=1.[CH3:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([CH2:19][CH2:20][NH2:21])=[CH:17][CH:16]=1>O>[NH2:1][C:2]1[C:7]([N:8]=[O:9])=[C:6]([NH2:10])[N:5]=[C:4]([NH:21][CH2:20][CH2:19][C:18]2[CH:22]=[CH:23][C:15]([O:14][CH3:13])=[CH:16][CH:17]=2)[N:3]=1

Komponenten

4

Edukt 2

HCID 4657O-MethyltyramineHCID 3276844,6-Pyrimidinediamine, 2-(methylthio)-5-nitroso-

Produkt 1

HCID 18982108HCID 18982108, VerbindungAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

The starting material was prepared as follows:-1) A mixture of 4,6-diamino-2-methylthio-5-nitrosopyrimidine (10 g, 5.4 mM), 4-methoxyphenethylamine (7.92 ml, 5.4 mM) and water (180 ml) was heated to reflux for one hour. After cooling the red solid was separated by filtration, washed with water, and dried. There was thus obtained 4,6-diamino-2-[2-(4-methoxyphenyl)-ethyl]amino-5-nitrosopyrimidine (13.4 g, 84% yield). NMR: DMSO-d6 ; 2.7-2.85(m,2H, CH2 --CH2), 3.4-3.6(m, 2H, CH2 --NH), 3.7 (s, 3H, OCH3), 6.75-6.8(m,2H, aromatic-H), 7.05-7.25 (m, 2H, aromatic-H), 7.4-10.5 (m,5H, NH2 ×2, NH), m/e [M+H[+ 289.

Aufarbeitung

  1. customThe starting material was prepared
  2. temperaturewas heated
  3. temperatureto reflux for one hour
  4. temperatureAfter cooling the red solid
  5. customwas separated by filtration
  6. washwashed with water
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-3a30147a0f8b49088dbc06ba2cc25cbe
Quelldatensatz
uspto-grants-1996_03
Patentnummer
US05500428

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