HCID 22185398, Verbindung → HCID 22185405, Verbindung

HRID 1442651Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1442651
[CH3:1][O:2][C:3]1[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:4]=1[O:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.[H][H]>CCOC(C)=O.[Pd]>[CH3:1][O:2][C:3]1[CH:17]=[C:16]([NH2:18])[CH:15]=[CH:14][C:4]=1[O:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

Komponenten

5

Edukt 2

HCID 22185398HCID 22185398, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 22185405HCID 22185405, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of 10% Pd/C (0.25 g) was added to a solution of 4-[2-(2-methoxy-4-nitro-phenoxy)-ethyl]-morpholine Compound 42a3 (1.4 g, 5.0 mmol) in EtOAc (50 mL). The solution was exposed to 40 PSI of hydrogen gas for a period of 1 hr. The catalyst was removed by filtration through Celite 545 and the solvent was removed to give 3-methoxy-4-(2-morpholin-4-yl-ethoxy)-phenylamine Compound 42a (1.1 g). MS 253 (MH+).

Aufarbeitung

  1. customThe catalyst was removed by filtration through Celite 545
  2. customthe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-286890e9bbaf4481b916e52e78d4eafd
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07659284B2

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