Methyl 3-methyl-1-oxidopyridin-4-yl ether → 4-Methoxy-3-methylpyridine

HRID 1442893Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1442893
[CH3:1][C:2]1[CH:3]=[N+:4]([O-])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]>[Pd].CO>[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

Komponenten

4

Edukt 1

HCID 817250Methyl 3-methyl-1-oxidopyridin-4-yl ether

Produkt 1

HCID 47377664-Methoxy-3-methylpyridineAusbeute 90,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 4 g (28.8 mmol) 3-methyl-4-methoxy pyridine N-oxide (prepared according to the method described in Kohl, Bernhard et al; J. Med. Chem.; 1992; 1049-1057) and 1.1 mg of 5% palladium on charcoal in 50 ml of methanol is hydrogenated at 20 atms at room temperature for 12 hours (2*6 hours). Filtration through celite, and evaporation gave 3.2 g (90%) of a light green oil.

Aufarbeitung

  1. customprepared
  2. custom(2*6 hours)
  3. filtrationFiltration
  4. customthrough celite, and evaporation

Quellen und Nachweise

ORD-Eintrag
ord-58e9572b4857474babdd03919fd7ae43
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07659307B2

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