Methanol → 5-Methyl-1H-indazol-4-amine

HRID 1443220Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1443220
Cl[C:2]1[C:3]([NH2:11])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2.[CH3:12]O>[Pd]>[CH3:12][C:2]1[C:3]([NH2:11])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2

Komponenten

4

Edukt 2

HCID 887MethanolHCID 179892615-Chloro-1H-indazol-4-amine

Produkt 1

HCID 193544325-Methyl-1H-indazol-4-amineAusbeute 6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

Analogously to the production of 5-chloro-1H-indazol-4-ylamine, the regioisomeric mixture of the previous reaction (1.0 g, 5.64 mmol)) is reacted with 100 mg of palladium on carbon in methanol under hydrogen atmosphere for 16 hours at room temperature. After purification on silica gel with hexane/ethyl acetate (33% hexane, then 100% ethyl acetate), 53 mg (6% of theory) of 5-methyl-1H-indazol-4-ylamine is obtained.

Aufarbeitung

  1. customAfter purification on silica gel with hexane/ethyl acetate (33% hexane

Quellen und Nachweise

ORD-Eintrag
ord-bbca41883f3043539429aa866db67940
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07659297B2

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