Sodium Hydroxide → 5-Phenylfuran-2-carboxylic acid

HRID 1444203Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1444203
[OH-].[Na+].C[O:4][C:5]([C:7]1[O:8][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:10][CH:11]=1)=[O:6]>O.CO>[C:12]1([C:9]2[O:8][C:7]([C:5]([OH:6])=[O:4])=[CH:11][CH:10]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 11275689Methyl 5-phenylfuran-2-carboxylate

Produkt 1

HCID 7362555-Phenylfuran-2-carboxylic acidAusbeute 97,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of sodium hydroxide (200 mg) in water (5 ml) was added to a stirred solution of 5-phenyl-furan-2-carboxylic acid methyl ester (7) (384 mg, 1.90 mmoles) in methanol (20 ml) and the mixture was stirred at room temperature for 4 hours. The solvent was evaporated and the residue was diluted with water (10 ml) and acidified to pH=2 with 1 M aqueous hydrochloric acid. The precipitate was collected, washed with water and the residue was triturated with cyclohexane to afford (8) (350 mg) as a white solid. LC/MS System A; Rt=3.89 mins.

Aufarbeitung

  1. customThe solvent was evaporated
  2. additionthe residue was diluted with water (10 ml)
  3. customThe precipitate was collected
  4. washwashed with water
  5. customthe residue was triturated with cyclohexane

Quellen und Nachweise

ORD-Eintrag
ord-eb9ea6368dcc41dd96d31788d0675df0
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07662839B2

Notizen zur Reaktion

Wird geladen…