Methyl 3-(methyl(pentyl)amino)propanoate → N-Methyl-N-pentyl-beta-alanine

HRID 1444845

Reaktionsgleichung

Reaktionsgleichung von HRID 1444845
C[O:2][C:3](=[O:13])[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]>O>[CH3:12][N:6]([CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[CH2:5][CH2:4][C:3]([OH:13])=[O:2]

Komponenten

3

Edukt 1

HCID 16726422Methyl 3-(methyl(pentyl)amino)propanoate

Produkt 1

HCID 16036977N-Methyl-N-pentyl-beta-alanine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

68.8 g (367.4 mmol) N-methyl-N-pentyl-β-alanine methyl ester was hydrolyzed by refluxing with 138 ml water. Water was distilled off and 300 ml diethyl carbonate were added, followed by azeotropic distillation of diethyl carbonate/water (30 ml) to remove residual water. About 290 ml of a diethyl carbonate solution containing 63 g N-methyl-N-pentyl-β-alanine was obtained which could directly be used for the subsequent bisphosphorylation step.

Aufarbeitung

  1. distillationWater was distilled off
  2. addition300 ml diethyl carbonate were added
  3. distillationfollowed by azeotropic distillation of diethyl carbonate/water (30 ml)
  4. customto remove residual water
  5. additionAbout 290 ml of a diethyl carbonate solution containing 63 g N-methyl-N-pentyl-β-alanine
  6. customwas obtained which

Quellen und Nachweise

ORD-Eintrag
ord-61203c1e27a947bb92be1994604cf1c6
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07662990B2

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