1,3-Dibromopropane → 2-[4-(3-Bromopropoxy)phenyl]ethanol

To a solution of 4-hydroxyphenethyl alcohol (4.37 g, 31.0 mmol) and potassium carbonate (6.55 g, 47.0 mmol) in acetonitrile (62.0 mL) was added 1,3 dibromopropane (31.0 mL, 316 mmol). The reaction mixture was heated to 70° C. for 12 hours and then cooled to room temperature, filtered and concentrated under vacuum. The resulting oil was purified by silica gel chromatography using a mixture of 4:1 hexanes and ethyl acetate to give the title compound (6.21 g) as a white solid.

1. temperaturecooled to room temperature
2. filtrationfiltered
3. concentrationconcentrated under vacuum
4. customThe resulting oil was purified by silica gel chromatography
5. additiona mixture of 4:1 hexanes and ethyl acetate

ORD-Eintrag

ord-93f3d96d34ad4634b129237859851a50

Quelldatensatz

uspto-grants-2010_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07732441B2