Diisopropylethylamine → HCID 59170135, Verbindung

HRID 1446279

Reaktionsgleichung

Reaktionsgleichung von HRID 1446279
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:13])[CH2:12][CH2:11][NH:10][CH2:9]2)=[CH:4][CH:3]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N(C(C)C)C(C)C)C.[CH3:45][C:46]1[CH:51]=[CH:50][C:49]([C:52]2[C:56]([C:57](O)=[O:58])=[CH:55][O:54][N:53]=2)=[CH:48][CH:47]=1>CN(C=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([OH:13])[CH2:12][CH2:11][N:10]([C:57]([C:56]3[C:52]([C:49]4[CH:50]=[CH:51][C:46]([CH3:45])=[CH:47][CH:48]=4)=[N:53][O:54][CH:55]=3)=[O:58])[CH2:9]2)=[CH:6][CH:7]=1

Komponenten

6

Edukt 4

HCID 81531DiisopropylethylamineHCID 2005573-(4-Fluorophenyl)pyrrolidin-3-olHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 588287973-(4-Methylphenyl)isoxazole-4-carboxylic acid

Produkt 1

HCID 59170135HCID 59170135, VerbindungAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of 3-(4-fluorophenyl)pyrrolidin-3-ol (9 mg, 0.039 mmol), TBTU (15 mg, 0.047 mmol, 1.2 equ.) and N-ethyl-N-isopropylpropan-2-amine (14 μL, 0.079 mmol, 2 equ.) in DMF (0.3 mL) was added to 3-(4-methylphenyl)isoxazole-4-carboxylic acid (8 mg, 0.039 mmol) and the reaction mixture was stirred at rt for 2 h. The solvent was evaporated and the crude product was purified by RP-HPLC. After evaporation of the solvents the product was dried in vacuum to yield the title compound (10 mg). MS (ESI, pos. ion) m/z calcd for C21H19FN2O3: 366.1380, found 366.1381.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe crude product was purified by RP-HPLC
  3. customAfter evaporation of the solvents the product
  4. customwas dried in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-5dbde8d2c7fe4793a333af6ab48969ec
Quelldatensatz
uspto-grants-2010_02
Patentnummer
US07666888B2

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