Ethyl 2-chloropropionate → Ethyl 2-[4-[4-(trifluoromethyl)phenoxy]phenoxy]propanoate

HRID 1446899Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1446899
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:16]=[CH:15][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.Cl[CH:20]([CH3:26])[C:21]([O:23][CH2:24][CH3:25])=[O:22].C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C>[F:1][C:2]([F:17])([F:18])[C:3]1[CH:16]=[CH:15][C:6]([O:7][C:8]2[CH:9]=[CH:10][C:11]([O:14][CH:20]([CH3:26])[C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:12][CH:13]=2)=[CH:5][CH:4]=1

Komponenten

5

Edukt 3

HCID 10807Ethyl 2-chloropropionateHCID 11430Potassium CarbonateHCID 170230p-(4-(Trifluoromethyl)phenoxy)phenol

Produkt 1

HCID 631921Ethyl 2-[4-[4-(trifluoromethyl)phenoxy]phenoxy]propanoateAusbeute 54 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6569Methyl Ethyl KetoneLösungsmittel

Versuchsvorschrift

A solution of 73.5 g of 4-(4-trifluoromethylphenoxy)phenol and 49.2 g of ethyl α-chloropropionate and 100 g of potassium carbonate were added to 100 ml of methyl ethyl ketone, and the mixture was heated. With stirring, the reaction was performed for 10 hours at the reflux temperature (80° to 85° C.). Inorganic salts were separated from the reaction product by filtration. The filtrate was evaporated and dried. The resulting ester was extracted with chloroform, and washed with water. The chloroform was distilled off to afford 55 g of the final product (yield: 54%). The final product had a boiling point of 176° to 185° C./3 mmHg.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. customInorganic salts were separated from the reaction product by filtration
  3. customThe filtrate was evaporated
  4. customdried
  5. extractionThe resulting ester was extracted with chloroform
  6. washwashed with water
  7. distillationThe chloroform was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-61e0b408a9a845d2b5bb1b6073bfc49e
Quelldatensatz
uspto-grants-1982_02
Patentnummer
US04314069

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