3-amino-1H-pyrazole-4,5-dicarbonitrile → 3-Cyano-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo-[1,5-a]pyrimidine-2-carbonitrile

HRID 1447882

Reaktionsgleichung

Reaktionsgleichung von HRID 1447882
C[N:2]([CH3:17])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)=O.[NH2:18][C:19]1[C:23](C#N)=[C:22]([C:26]#[N:27])[NH:21][N:20]=1>C(O)(=O)C>[C:19]([C:23]1[C:22]([C:26]#[N:27])=[N:21][N:20]2[C:5]([C:7]3[CH:8]=[C:9]([C:13]([F:14])([F:15])[F:16])[CH:10]=[CH:11][CH:12]=3)=[CH:4][CH:3]=[N:2][C:17]=12)#[N:18]

Komponenten

4

Edukt 2

HCID 3388303-amino-1H-pyrazole-4,5-dicarbonitrileHCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenone

Produkt 1

HCID 113704003-Cyano-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo-[1,5-a]pyrimidine-2-carbonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 4.86 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 50 ml. of glacial acetic acid and 2.66 g. of 3-aminopyrazole-4,5-dicarbonitrile is refluxed for 10 hours and the solvent removed under reduced pressure. The residue is treated with trifluoroacetic anhydride to give the product of the example. cl EXAMPLE 44

Aufarbeitung

  1. additionA mixture of 4.86 g
  2. customthe solvent removed under reduced pressure
  3. additionThe residue is treated with trifluoroacetic anhydride
  4. customto give the product of the example

Quellen und Nachweise

ORD-Eintrag
ord-3be5e32ab22c44608da2087ba1faac10
Quelldatensatz
uspto-grants-1979_12
Patentnummer
US04178449

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