Sodium Cyanide → 3-Fluoro-4-methoxyphenylacetonitrile

HRID 1447930

Reaktionsgleichung

Reaktionsgleichung von HRID 1447930
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[C:5]([F:11])[CH:4]=1.[CH2:12]([N:18](CCCCCC)CCCCCC)CCCCC.[C-]#N.[Na+]>O>[F:11][C:5]1[CH:4]=[C:3]([CH2:2][C:12]#[N:18])[CH:8]=[CH:7][C:6]=1[O:9][CH3:10]

Komponenten

5

Edukt 3

HCID 8929Sodium CyanideHCID 66022TrihexylamineHCID 27745534-(Bromomethyl)-2-fluoro-1-methoxybenzene

Produkt 1

HCID 1362513-Fluoro-4-methoxyphenylacetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 4-(bromomethyl)-2-fluoroanisole (45.8 g, 0.21 mol), trihexylamine (1.4 g) and sodium cyanide (20.5 g, 0.42 mol) in water (50 ml) is heated at 60°-65° C. for 18 hours. The mixture is cooled and extracted in its ether, washed with water, saturated sodium chloride solution and dried (CNa2SO4). Evaporation of the solvent gives a solid, (33.2 g): m.p. 42°-46° C.

Aufarbeitung

  1. temperatureis heated at 60°-65° C. for 18 hours
  2. temperatureThe mixture is cooled
  3. extractionextracted in its ether
  4. washwashed with water, saturated sodium chloride solution
  5. dry with materialdried (CNa2SO4)
  6. customEvaporation of the solvent
  7. customgives a solid, (33.2 g)

Quellen und Nachweise

ORD-Eintrag
ord-0774a4ac458a4713bcbe32312b9f326f
Quelldatensatz
uspto-grants-1979_12
Patentnummer
US04178460

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