Water → 4,5-Dichloro-N'-phenyl-1H-imidazole-2-carbohydrazide

HRID 1447966Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1447966
CS[C:3]([C:5]1[NH:6][C:7]([Cl:11])=[C:8]([Cl:10])[N:9]=1)=[O:4].[C:12]1([NH:18][NH2:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.O>C(O)C>[C:12]1([NH:18][NH:19][C:3]([C:5]2[NH:6][C:7]([Cl:11])=[C:8]([Cl:10])[N:9]=2)=[O:4])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 7516PhenylhydrazineHCID 536468924,5-dichloro-imidazole-2-thiocarboxylic acid S-methyl ester

Produkt 1

HCID 540087254,5-Dichloro-N'-phenyl-1H-imidazole-2-carbohydrazideAusbeute 50 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

21.1 g (0.1 mol) of 4,5-dichloro-imidazole-2-thiocarboxylic acid S-methyl ester were boiled with 10.8 g (0.1 mol) of phenylhydrazine in 150 ml of ethanol for 4 hours under reflux. The cooled reaction mixture was mixed with 500 ml of water and the crystals which had separated out were filtered off and dried. 13.5 g (50% of theory) of 4,5-dichloro-imidazole-2-carboxylic acid N'-phenyl-hydrazide with a melting point of 229°-230° C. (from ethyl acetate) were obtained.

Aufarbeitung

  1. temperatureunder reflux
  2. customThe cooled reaction mixture
  3. customthe crystals which had separated out
  4. filtrationwere filtered off
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-292accddab874fae84801bd250e8ae1c
Quelldatensatz
uspto-grants-1979_12
Patentnummer
US04179277

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