HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethanol → 2-Phthalimidomethyl-6-methyl-4-(-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethanol | HCID 702 | — |
| Edukt | 3-Pyridinecarboxaldehyde | HCID 10371 | — |
| Edukt | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Edukt | Ethyl 4-(1,3-dioxoisoindolin-2-YL)-3-oxobutanoate | HCID 701239 | — |
| Produkt | 2-Phthalimidomethyl-6-methyl-4-(-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 70590121 | 65% |
Reaktionsschritte
A solution of 4.7 ccs of pyridine-3-aldehyde, 12.4 g of phthalimidoacetoacetic acid ethyl ester and 5.85 g of β-aminocrotonic acid ethyl ester in 100 ccs of ethanol is heated under reflux for 24 hours and, after cooling and filtering, crystals (beige) of melting point 165° C. are obtained, yield: 65%.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04188395 |
| Quelldatensatz | uspto-grants-1980_02 |
| ORD ID | ord-37f2c0327a4a4334b7309a293b2b0a7c |
| Quellennotiz | uspto-grants-1980_02 |