Hydrochloric Acid → 2-(2-Indenyl)-3-methylbutanoic acid

HRID 1449228Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1449228
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[CH:10]([CH:28]([CH3:30])[CH3:29])[C:11]([O:13]CC1C=CC=C(OC2C=CC=CC=2)C=1)=[O:12].[OH-].[K+].C(O)C.Cl>O>[CH2:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:1]=[C:2]1[CH:10]([CH:28]([CH3:30])[CH3:29])[C:11]([OH:13])=[O:12]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 13146349m-Phenoxylbenzyl 2-(2-indenyl)-3-methylbutanoate

Produkt 1

HCID 233470912-(2-Indenyl)-3-methylbutanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of m-phenoxylbenzyl 2-(2-indenyl)-3-methylbutanoate (8 mmol), potassium hydroxide (24 mmol), ethanol (25 ml) and water (4 ml) is heated to reflux for about 3 hours. After cooling, the reaction is acidified with dilute hydrochloric acid. The mixture is extracted with ether, and the ether phase is washed to neutrality with saturated NaCl solution. Removal of solvent by evaporation yields 2-(2-indenyl)-3-methylbutanoic acid.

Aufarbeitung

  1. temperatureis heated
  2. temperatureto reflux for about 3 hours
  3. temperatureAfter cooling
  4. extractionThe mixture is extracted with ether
  5. washthe ether phase is washed to neutrality with saturated NaCl solution
  6. customRemoval of solvent
  7. customby evaporation

Quellen und Nachweise

ORD-Eintrag
ord-45b060fe13b245248a2d3e41a7f388b2
Quelldatensatz
uspto-grants-1980_02
Patentnummer
US04189598

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