N-Iodosuccinimide → 3-(4-Chlorophenyl)-7-hydroxy-8-iodo-2-isopropyl-chromen-4-one

HRID 14496

Reaktionsgleichung

Reaktionsgleichung von HRID 14496
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17](=[O:18])[C:16]3[C:11](=[CH:12][C:13]([OH:19])=[CH:14][CH:15]=3)[O:10][C:9]=2[CH:20]([CH3:22])[CH3:21])=[CH:4][CH:3]=1.[I:23]N1C(=O)CCC1=O>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:17](=[O:18])[C:16]3[C:11](=[C:12]([I:23])[C:13]([OH:19])=[CH:14][CH:15]=3)[O:10][C:9]=2[CH:20]([CH3:22])[CH3:21])=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 120273N-IodosuccinimideHCID 162024513-(4-Chlorophenyl)-7-hydroxy-2-isopropyl-chromen-4-one

Produkt 1

HCID 597242463-(4-Chlorophenyl)-7-hydroxy-8-iodo-2-isopropyl-chromen-4-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

3-(4-Chlorophenyl)-7-hydroxy-2-isopropyl-chromen-4-one (2.3 g, 7.31 mmol) is suspended in dry dichloromethane (140 ml) at room temperature. N-iodosuccinimide (1.73 g, 7.67 mmol) is added, and the mixture is stirred vigorously at room temperature for 30 min. The mixture is diluted with dichloromethane (60 ml), washed with water (3×100 ml) and saturated brine (50 ml), dried (MgSO4) and filtered, and the filtrate is evaporated to give a pale pink solid.

Aufarbeitung

  1. washwashed with water (3×100 ml) and saturated brine (50 ml)
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. customthe filtrate is evaporated
  5. customto give a pale pink solid

Quellen und Nachweise

ORD-Eintrag
ord-d432949c0c7046e1843b5cf1467f7cf1
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732435B2

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