1-Iodpyrrolidin-2,5-dion

N-Iodosuccinimide

HCID 120273CAS 516-12-1
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Grundinformationen

Standard-SMILES
O=C1CCC(=O)N1I
InChIKey
LQZMLBORDGWNPD-UHFFFAOYSA-N
Summenformel
C4H4INO2
Durchschnittliche Molmasse
224,98 g/mol
Monoisotopische Masse
224,92868

Namen und Bezeichner

Bevorzugter Name
N-Iodosuccinimide
IUPAC
1-iodopyrrolidine-2,5-dione
Lokaler Name
1-Iodpyrrolidin-2,5-dion
Englischer Name
N-Iodosuccinimide
Summenformel
C4H4INO2
Molmasse
224.98

Namen und Synonyme

N-Iodosuccinimide516-12-11-Iodopyrrolidine-2,5-dioneSucciniodimide2,5-Pyrrolidinedione, 1-iodo-1-iodo-2,5-pyrrolidinedione3COS3X3N4PCHEBI:53204DTXSID10199550RefChem:163587DTXCID70122041208-221-6
Weitere Namen anzeigen
IodosuccinimideN-lodosuccinimide1-iodo-5-pyrrolidinedioneN-iododiimideN-Iodouccinimide
N-Iodosuccinimide (NIS)C4H4INO2MFCD00005512Succinimide, N-iodo-NISUNII-3COS3X3N4PEINECS 208-221-62,5-Dioxo-1-iodopyrrolidine

Datenbank-Bezeichner

CAS
516-12-1
PubChem CID
120273
DTXSID
DTXSID10199550
ChEBI
CHEBI:53204
UNII
3COS3X3N4P
EC Number
208-221-6
Nikkaji
J6.303G

Eigenschaften

Berechnete Struktureigenschaften

XLogP
-0,2
Polarare Oberfläche (TPSA)
37,4 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
2
Frei drehbare Bindungen
0
Schwere Atome
8

Physikochemische Eigenschaften

Schmelzpunkt
202 · 202-206 °C(lit.)
Siedepunkt
249.6 · 249.6±23.0 °C(Predicted)
Dichte
2 · 2,245 g/cm3
storage temp.
2 · 2-8°C
Löslichkeit
Soluble in dioxane, tetrahydrfuran and acetonitrile. Insoluble in ether and carbon tetrachloride.
pka
-2.57 · -2.57±0.20(Predicted)

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 6 Einträge

This chemical does not meet GHS hazard criteria for 8% (7 of 87) of reports.

Warning

H302 (85.1%): Harmful if swallowed [Warning Acute toxicity, oral]；H315 (90.8%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (90.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (87.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 87 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 7 of 87 reports by companies.；There are 17 notifications provided by 80 of 87 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Gefahrenhinweise

Regulatory Information · 2 Einträge

Status: Active Update: 17-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/25034

2,5-Pyrrolidinedione, 1-iodo-: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesAcute Tox. 4 (85.1%)；Skin Irrit. 2 (90.8%)；Eye Irrit. 2 (90.8%)；STOT SE 3 (87.4%)

Regulatorische Informationen

Regulatory Information · 2 Einträge

Status: Active Update: 17-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/25034

2,5-Pyrrolidinedione, 1-iodo-: Does not have an individual approval but may be used under an appropriate group standard

Sicherheitsdaten

F
8-9
wgk
3
tsca
No
hs_code
29251995
RTECS-Nr.
WN2817000
risk_code
22-36/37/38

Chemie und Industrie

Anwendungen

VerwendenN-Iodosuccinimide is a iodo substituted succinimide that is used as an iodinating agent in chemical synthesis.

Darstellung · 1 Eintrag

synthetischeTo a solution of 39.2g of succinimide in 1200ml of boiling water was added 51.0g of freshly precipitated silver oxide, the mixture was filtered and the silver salt was allowed to crystallize. Filtration and washing with cold water furnished 45.0g of the silver salt of succinimide suitable for the iodination step. The finely powdered salt (49.5g) was added in portions with stirring to a solution of 50.8g of iodine in 300ml of acetone, the temperature being maintained at 5-10°C. After decolorization (30 min.), the silver iodide was filtered, the solvent was removed under reduced pressure at room temperature and the residue was washed with ether, yielding 43g of N-iodosuccinimide with mp 189-191°C. An analytical sample (85% recovery) was obtained by dissolving in the minimum quantity of hot dioxane and precipitating with carbon tetrachloride; colorless needles, mp 200-201°C. Ref: JACS 75, 3493 (1953)

Vor- und nachgelagerte Produkte

Anbieter50 Anbieter

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
宁波君龙新材料有限公司0574 88552216 19032109277 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]
爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

Ergänzende Hinweise

DefinitionChEBI: N-iodosuccinimide is a five-membered cyclic dicarboximide compound having an iodo substituent on the nitrogen atom. It is a dicarboximide and a pyrrolidinone. It derives from a succinimide.

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