HCID 67646998, Verbindung → 3-(1-(BOC-amino)-1-cyclopropyl-methyl)pyrrolidine

HRID 1450099Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1450099
[C:1]([NH:8][CH:9]([CH:13]1[CH2:17][CH2:16][N:15](CC2C=CC=CC=2)[CH2:14]1)[CH:10]1[CH2:12][CH2:11]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>CO.[Pd]>[C:1]([NH:8][CH:9]([CH:13]1[CH2:17][CH2:16][NH:15][CH2:14]1)[CH:10]1[CH2:11][CH2:12]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Komponenten

4

Edukt 1

HCID 67646998HCID 67646998, Verbindung

Produkt 1

HCID 196914723-(1-(BOC-amino)-1-cyclopropyl-methyl)pyrrolidineAusbeute 35,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A sample (548 mg) of the compound from step 470d was dissolved in methanol, 140 mg of 10% Pd/C was added, and the mixture was hydrogenated at 4 arm H2 for 42 hours at room temperature. The solution was filtered, and the solvent was removed to give 140 mg of the title compound.

Aufarbeitung

  1. filtrationThe solution was filtered
  2. customthe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-1c5f3cedde6f49e5b85f80ea76afab0a
Quelldatensatz
uspto-grants-1997_02
Patentnummer
US05599816

Notizen zur Reaktion

Wird geladen…