Chloroacetone → 1-((4-Bromophenyl)thio)propan-2-one

HRID 1450502Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1450502
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.[OH-].[Na+].Cl[CH2:12][C:13](=[O:15])[CH3:14]>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:12][C:13](=[O:15])[CH3:14])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 6571ChloroacetoneHCID 14798Sodium HydroxideHCID 660494-Bromothiophenol

Produkt 1

HCID 8219021-((4-Bromophenyl)thio)propan-2-oneAusbeute 104,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a stirred solution of 4-bromothiophenol (5.09 g, 26.9 mmol) in NaOH (1.08 g, 26.9 mmol) and water (32 ml) was added chloroacetone (2.17 ml, 27.3 mmol) and the mixture was stirred under nitrogen for 45min before extracting with ether, washing with water, drying (Na2SO4) and evaporating in vacuo, leaving 6.89 g (100%) of the title compound as a white solid, δ (CDCl3) 2.27 (3H, s), 3.65 (2H, s), 7.20 (2H, d, J=8.5 Hz), 7.41 (2H, d, J=8.5 Hz).

Aufarbeitung

  1. extractionbefore extracting with ether
  2. washwashing with water
  3. dry with materialdrying (Na2SO4)
  4. customevaporating in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-393e749c4d714c248d2930b667945919
Quelldatensatz
uspto-grants-1997_02
Patentnummer
US05602163

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