Sodium Carbonate → Abiraterone

HRID 1451372

Reaktionsgleichung

C(B(CC)[C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)C.I[C:13]1[C@:14]2([CH2:31][CH2:30][C@H:29]3[C@@H:19]([CH2:20][CH:21]=[C:22]4[C@:27]3([CH3:28])[CH2:26][CH2:25][C@H:24]([OH:32])[CH2:23]4)[C@@H:16]2[CH2:17][CH:18]=1)[CH3:15].C(=O)([O-])[O-].[Na+].[Na+]>C1COCC1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.Cl[Pd]Cl>[N:6]1[CH:7]=[CH:8][CH:9]=[C:4]([C:13]2[C@:14]3([CH2:31][CH2:30][C@H:29]4[C@@H:19]([CH2:20][CH:21]=[C:22]5[C@:27]4([CH3:28])[CH2:26][CH2:25][C@H:24]([OH:32])[CH2:23]5)[C@@H:16]3[CH2:17][CH:18]=2)[CH3:15])[CH:5]=1

Komponenten

Reaktionsbedingungen

Temperatur: 80 °C

Versuchsvorschrift

Diethyl(3-pyridyl)borane (3.23 g, 22 mmol) from Aldrich Chemical Co. Ltd. was added to a stirred solution of 17-iodo-androsta-5,16-dien-3β-ol (7.96 g, 20 mmol) in THF (120 ml) containing bis(triphenylphosphine)palladium (II) chloride (140 mg, 0.2 mmol). An aqueous solution of sodium carbonate (2M, 50 ml) was then added and the mixture heated, with stirring, by an oil bath at 80° C. for 48 h, and allowed to cool.

Aufarbeitung

temperaturethe mixture heated
temperatureto cool

Quellen und Nachweise

ORD-Eintrag: ord-5029af42076341ff9378a6e5e5514c99
Quelldatensatz: uspto-grants-1997_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05604213

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