Triethylamine → HCID 54069381, Verbindung

HRID 1451784Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1451784
C(N(CC)CC)C.[NH2:8][CH2:9][CH:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:19]3[CH:20]=[CH:21][C:22](=[O:25])[NH:23][N:24]=3)[CH:16]=2)[CH2:11]1.Br.[CH2:27]([N:30]=[C:31]=[O:32])[CH:28]=[CH2:29]>COCCO>[CH2:27]([NH:30][C:31]([NH:8][CH2:9][CH:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:19]3[CH:20]=[CH:21][C:22](=[O:25])[NH:23][N:24]=3)[CH:16]=2)[CH2:11]1)=[O:32])[CH:28]=[CH2:29]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 15123Allyl isocyanateHCID 214762912-aminomethyl-5-[pyridazin-3(2H)-on-6-yl]indane hydrobromide

Produkt 1

HCID 54069381HCID 54069381, VerbindungAusbeute 86,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80192-MethoxyethanolLösungsmittel

Versuchsvorschrift

Triethylamine (1.05 g) was added to 40 ml of a suspension containing 2.70 g of 2-aminomethyl-5-[pyridazin-3(2H)-on-6-yl]indane·hydrobromide suspended in 2-methoxyethanol, and the mixture was stirred at room temperature for 10 minutes. To the mixture was added 1.10 g of allyl isocyanate, and the resulting mixture was stirred at room temperature for 1.5 hours. The reaction mixture was poured into ice water, and crystals precipitated were collected by filtration. The crystals obtained were washed with water, dried and then recrystallized from methanol to obtain 2.35 g of 2-[(ALLYLCARBAMOYL) amino]methyl-5-[pyridazin-3(2H)-on-6-yl]indane.

Aufarbeitung

  1. stirringthe resulting mixture was stirred at room temperature for 1.5 hours
  2. customprecipitated
  3. filtrationwere collected by filtration
  4. customThe crystals obtained
  5. washwere washed with water
  6. customdried
  7. customrecrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-52d0bc0e0745418caaff364033ff91f2
Quelldatensatz
uspto-grants-1997_02
Patentnummer
US05605901

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