Oxalyl chloride → 4-Fluorobenzoyl isocyanate

HRID 1452516

Reaktionsgleichung

Reaktionsgleichung von HRID 1452516
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.C(Cl)(=O)[C:12](Cl)=[O:13]>ClCCl>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:8]=[C:12]=[O:13])=[O:7])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 65578Oxalyl chlorideHCID 715724-Fluorobenzamide

Produkt 1

HCID 27333754-Fluorobenzoyl isocyanate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1.5 g of 4-fluorobenzamide was dissolved in 20 ml of dichloromethane and 2.3 ml of oxalyl chloride was slowly added thereto at room temperature, and then the mixutre was heated and refluxed for 16 hours. When the reaction was completed, the reaction mixture was cooled to room temperature and the solvent was distilled under reduced pressure to produce the titled compound as a oil. Without purification processes, next process was proceeded.

Aufarbeitung

  1. temperaturerefluxed for 16 hours
  2. temperaturethe reaction mixture was cooled to room temperature
  3. distillationthe solvent was distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6f7e71e2837f4a44b05ef245dccab01d
Quelldatensatz
uspto-grants-2009_01
Patentnummer
US07473700B2

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